| 溶解性 | Soluble in DMSO (50 mM), methanol, and ethanol (<1 mg/ml at 25 °C). Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
| 应用 | A SERM of ERα and ERβ. |
| 产品介绍 | Raloxifene HCl是estrogen（雌性激素）拮抗剂，抑制人体胞浆醛氧化酶催化的酞嗪氧化活性，IC50为5.7 nM。 |
| 备注 | Raloxifene is estrogen antagonists, inhibits human cytosolic aldehyde oxidase-catalyzed phthalazine oxidation activity with IC50 of 5.7 nM. |
| 生化机理 | Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor. |
| 别名 | 盐酸雷洛昔芬; [6-羟基-2-(4-羟苯基)苯并[b]噻酚-3-基]-[4-[2-(1-哌啶基)乙氧基]-苯基]-甲酮盐酸盐;Raloxifene Hydrochloride;keoxifene;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride |
雷洛昔芬盐酸盐
Raloxifene HCl （订货以英文为准）
编号：R129396
CAS号：82640-04-8
分子式：C28H28CLNO4S
分子量：510.04
| 产品名称 | Raloxifene HCl |
| 中文名称 | 雷洛昔芬盐酸盐 |
| CAS号 | 82640-04-8 |
| 分子式（M.F.） | C28H28CLNO4S |
| 分子量（M.W.） | 510.04 |
| 储存条件 | -20°C储存 |
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