Galeterone,CYP17抑制剂

Galeterone (订货以英文为准)

编号:T127853
CAS号:851983-85-2
分子式:C26H32N2O
分子量:388.56
货号 品牌 包装 目录价 您的价格 库存 数量 购买
T127853-100mg 阿拉丁 100mg ¥2020.90
T127853-25mg 阿拉丁 25mg ¥1012.90
T127853-5mg 阿拉丁 5mg ¥576.90
产品名称 Galeterone
中文名称 Galeterone,CYP17抑制剂
CAS号 851983-85-2
分子式(M.F.) C26H32N2O
分子量(M.W.) 388.56
储存条件 -20°C储存
溶解性DMSO 24 mg/mL Water <1 mg/mL Ethanol 40 mg/mL
存贮条件储存温度-20°C
应用An antagonist to LNCaP AR
产品介绍TOK-001 (VN/124-1; Galeterone)是多功能抗雄激素和CYP17抑制剂,IC50为47 nM。
备注Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.
生化机理Galeterone is effective at preventing binding of [3H]-R1881 to the mutant LNCaP AR (T877A) and to T575A mutant AR in PC3 cells with IC50 values of 845 nM and 454 nM, respectively. The effects on AR significantly reduce cellular phospho-4EBP1 levels. Galeterone potently inhibits the proliferation of LNCaP and LAPC4 cells in the with IC50 values of 2.6 μM and 4 μM, respectively. Galeterone induces the endoplasmic reticulum s.tress response resulting in down-regulation of cyclin D1 protein expression and cyclin E2 mRNA. in vitro.
别名TOK001;TOK 001;TOK-001;(3beta)-17-(1H-苯并咪唑-1-基)雄甾-5,16-二烯-3-醇;VN-124-1;VN/124-1;VN 124;3β-Hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene
个人防护设备Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国3
搜索质检报告(COA)
搜索MSDS
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