| 沸点 | 590.48° C at 760 mmHg |
| 熔点 | 239.35° C |
| 折光率 | 1.68 |
| 溶解性 | DMSO 62 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3300 |
| 应用 | An antiproliferating agent and ATP-competitive PDGFR, Flk-1/KDR (VEGF), and FGFR inhibitor |
| 产品介绍 | TSU-68 (SU6668; Orantinib)是多酪氨酸激酶受体抑制剂，对PDGFR自磷酸化抑制性最强，Ki为8 nM，还能相对弱地抑制VEGF-R1和FGF-R1。 |
| 备注 | SU6668 has greatest potency against PDGFR autophosphorylation with Ki of 8 nM, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit |
| 生化机理 | TSU-68 (SU6668)is a novel multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 μM, 8 nM and 1.2 μM for VEGF-R1, PDGF-Rβ and FGF-R1, respectively. |
| 别名 | SU 6668;TSU68; 5-((1,2-二氢-2-氧代-3H-吲哚-3-亚基)甲基)-2,4-二甲基-1H-吡咯-3-丙酸;;Orantinib;TSU 68;SU6668； 5-(1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl)-2,4-dimethyl-1h-pyrrole-3-propanoic acid；3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; 3-[2, 4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl] propanoic acid |
TSU-68（SU6668，Orantinib）,PDGFR抑制剂
TSU-68 (SU6668, Orantinib) （订货以英文为准）
编号：T125079
CAS号：252916-29-3
分子式：C18H18N2O3
分子量：310.35
| 产品名称 | TSU-68 (SU6668, Orantinib) |
| 中文名称 | TSU-68（SU6668，Orantinib）,PDGFR抑制剂 |
| CAS号 | 252916-29-3 |
| 分子式（M.F.） | C18H18N2O3 |
| 分子量（M.W.） | 310.35 |
| 储存条件 | -20°C储存 |
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