| 溶解性 | DMSO 100 mg/mL (172.09 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM) |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | An antineoplastic agent used in breast cancer research |
| 产品介绍 | Lapatinib可形成Lapatinib的二甲苯磺酸盐，是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2和9.8 nM。 |
| 备注 | Lapatinib, used in the form of Lapatinib Ditosylate, is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM, respectively. |
| 生化机理 | Lapatinib is an antineoplastic agent used in breast cancer research research. It appears to be a tyrosine kinase inhibitor which interrupts the Neu/ ErbB2 and EGFR (epidermal growth factor receptor) pathways, thus inhibiting ErbB-overexpressing tumors. Lapatinib binds to the ATP-binding pocket of the protein kinase domains on EGFR/ErbB, preventing self-phosphorylation in solid tumor cells. Lapatinib is an inhibitor of EGFR and Neu/ ErbB2. |
| 别名 | 拉帕替尼;N-[3-氯-4-[(3-氟苯基)甲氧基]苯基]-6-[5-[(2-甲磺酰乙基氨基)甲基]-2-呋喃基]喹唑啉-4-胺;Tykerb;GW572016;GW-572016;GW 572016;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine |
拉帕替尼
Lapatinib （订货以英文为准）
编号：L126696
CAS号：231277-92-2
分子式：C29H26CLFN4O4S
分子量：581.06
| 产品名称 | Lapatinib |
| 中文名称 | 拉帕替尼 |
| CAS号 | 231277-92-2 |
| 分子式（M.F.） | C29H26CLFN4O4S |
| 分子量（M.W.） | 581.06 |
| 储存条件 | -20°C储存;充氩 |
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