| 熔点 | 150-160°C |
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol., Soluble in ethanol (10 mg/ml), water (45.45 mg/ml), chloroform, DMSO, and methanol. |
| 存贮条件 | 阴凉干燥，避光环境保存 |
| 密度 | 1.3200 |
| 应用 | 秋水仙碱是染色体研究中不可缺少的试剂。抗有丝分裂试剂，靠结合微管蛋白（tubulin）阻断微管聚合。 激活微管蛋白内在的GTPase活性。 在几种正常和肿瘤细胞株上诱导细胞凋亡，激活 JNK/SAPK 信号传导途径。 |
| 产品介绍 | 遇光变暗。易溶于乙醇、氯仿，溶于水、乙醚、苯，不溶于石油醚；溶解度:45g/L (20°C)、1g/220ml 乙醚、1g/100ml 苯。pK（20℃）=12.35，pH值5.9。因其氮原子在侧链上是酰胺结构，故不呈碱性。 |
| 生化机理 | Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin (IC50 = 3.2 μM). Studies indicate that Colchicine also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca2+ concentrations in cells which may also result in apoptosis. Since increased rate of mitosis is associated with cancer cell proliferation, blocking microtubule function with Colchicine has been used as an approach to anti-cancer therapy. For instance, Colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity (5 μmol/kg in a mouse model of gouty arthritis) and inhibits the deposition of uric acid, a key aspect in the treatment of gout. |
| 别名 | 秋水仙碱;秋水仙素7-Acetamido-6,7-dihydro-1,2,3,10-tetramethoxybenzo[a]heptalen-9(5H)-one N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide |
秋水仙碱
Colchicine （订货以英文为准）
编号：C106740
CAS号：64-86-8
分子式：C22H25NO6
分子量：399.44
| 产品名称 | Colchicine |
| 中文名称 | 秋水仙碱 |
| CAS号 | 64-86-8 |
| 分子式（M.F.） | C22H25NO6 |
| 分子量（M.W.） | 399.44 |
| 储存条件 | 避光;干燥 |
| 个人防护设备 | Eyeshields,Faceshields,Gloves |
| WGK德国 | 2 |
| 风险声明 (欧洲) | R36/37/38; |
| 安全声明（欧洲） | S26;S36; |
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