CUDC-101,HDAC,EGFR和HER2抑制剂

CUDC-101 (订货以英文为准)

编号:C127191
CAS号:1012054-59-9
分子式:C24H26N4O4
分子量:434.49
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C127191-250mg 阿拉丁 250mg ¥4948.90
C127191-25mg 阿拉丁 25mg ¥966.90
C127191-50mg 阿拉丁 50mg ¥1546.90
C127191-100mg 阿拉丁 100mg ¥2474.90
C127191-10mg 阿拉丁 10mg ¥518.90
产品名称 CUDC-101
中文名称 CUDC-101,HDAC,EGFR和HER2抑制剂
CAS号 1012054-59-9
分子式(M.F.) C24H26N4O4
分子量(M.W.) 434.49
储存条件 -20°C储存
溶解性DMSO ≥40mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
存贮条件储存温度-20°C
应用A potent inhibitor of HDACs and receptor tyrosine kinases
产品介绍CUDC-101是HDAC,EGFR和HER2抑制剂,IC50分别为4.4,2.4和15.7 nM。
备注CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1.
生化机理CUDC-101 inhibits the erlotinib-resistant EGFR mutant T790M although its effects are incomplete with an Amax of ~60% of peak enzyme activity after inhibition. CUDC-101 treatment increases the acetylation of histone H3 and H4, as well as the acetylation of non-histone substrates of HDAC such as p53 and α-tubulin, in a dose-dependant manner in various cancer cell lines. CUDC-101 also suppresses HER3 expression, Met amplification, and AKT reactivation in tumor cells.
别名7-((4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基)氧基)-N-羟基庚酰胺;;CUDC101;CUDC 101;7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-n-hydroxyheptanamide
搜索质检报告(COA)
搜索MSDS
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