| 溶解性 | DMSO 20 mg/mL heatWater <1 mg/mL Ethanol 3 mg/mL |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | LDK378是一种有效的ALK抑制剂，IC50为0.2 nM，作用于IGF-1R和InsR，选择性分别为40和35倍。 |
| 备注 | LDK378 is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. Phase 2. |
| 生化机理 | Description:IC50 Value: N /ALDK378 is a highly selective inhibitor of an important cancer target, anaplastic lymphoma kinase (ALK) [1].LDK378 has received Breakthrough Therapy designation by the US Food and Drug Administration (FDA) for the treatment of patients with anaplastic lymphoma kinase positive (ALK+) metastatic non-small cell lung cancer (NSCLC) who had progressed during treatment with, or were intolerant to, crizotinib.Approximately 3-8% of patients with NSCLC have the ALK gene mutation [1]. There are limited treatment options for patients with ALK+ NSCLC, who tend to be non-smokers and younger than NSCLC patients without an ALK translocation [2].in vitro: N/Ain vivo: N/AClinical trial: LDK-378 in Adult Patients With ALK-Activated NSCLC Previously Treated With Chemotherapy and Crizotinib . Phase 2 |
| 别名 | 色瑞替尼;LDK 378;LDK-378;5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine;ceritinib |
色瑞替尼
LDK378 （订货以英文为准）
编号：L127618
CAS号：1032900-25-6
分子式：C28H36N5O3SCL
分子量：558.14
| 产品名称 | LDK378 |
| 中文名称 | 色瑞替尼 |
| CAS号 | 1032900-25-6 |
| 分子式（M.F.） | C28H36N5O3SCL |
| 分子量（M.W.） | 558.14 |
| 储存条件 | -20°C储存 |
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