| 溶解性 | DMSO 95 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | BMS-833923 is an orally bioavailable Smoothened antagonist. Phase 2. |
| 生化机理 | Description:IC50 Value: 6-35 nM [1]BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS-833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway.in vitro: In vitro, BMS-833923 inhibits the expression of downstream effectors in the HH pathway (GLI1 and PTCH1) in cell lines that express wild-type SMO and those which express activated mutant forms of SMO (IC50values of 6-35 nM). In FACS-based binding assays, BMS-833923 inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM [1].in vivo: Pharmacodynamic studies show that BMS-833923 robustly inhibits HH pathway activity with along duration of action after a single oral dose in medulloblastoma and pancreatic carcinoma xenograft models. The pharmacodynamic effects of BMS-833923 observed in these models translate into tumor growth inhibition at well-tolerated doses [1].Clinical trial: Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923). Phase 2 |
| 别名 | XL139;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-;XL139;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]- |
BMS-83 3923,Smoothened抑制剂
BMS-833923 （订货以英文为准）
编号：B126389
CAS号：1059734-66-5
分子式：C30H27N5O
分子量：473.57
| 产品名称 | BMS-833923 |
| 中文名称 | BMS-83 3923,Smoothened抑制剂 |
| CAS号 | 1059734-66-5 |
| 分子式（M.F.） | C30H27N5O |
| 分子量（M.W.） | 473.57 |
| 储存条件 | -20°C储存 |
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