NVP-AUY922

NVP-AUY922 (订货以英文为准)

编号:N126962
CAS号:747412-49-3
分子式:C26H31N3O5
分子量:465.54
货号 品牌 包装 目录价 您的价格 库存 数量 购买
N126962-10mg 阿拉丁 10mg ¥535.90
N126962-5mg 阿拉丁 5mg ¥286.90
N126962-25mg 阿拉丁 25mg ¥1029.90
N126962-100mg 阿拉丁 100mg ¥2080.90
N126962-50mg 阿拉丁 50mg ¥1852.90
产品名称 NVP-AUY922
中文名称 NVP-AUY922
CAS号 747412-49-3
分子式(M.F.) C26H31N3O5
分子量(M.W.) 465.54
储存条件 -20°C储存
溶解性Soluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble).
存贮条件储存温度-20°C
应用A highly potent HSP90 inhibitor to HSP90α and HSP90β
产品介绍Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂,其对HSP90α/β的IC50为13 nM /21 nM,对HSP90家族成员GRP94和TRAP-1具有稍弱的作用,与任何HSP90配体均可紧密结合。Phase 2。
备注AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2.
生化机理NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of Hsp90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to Hsp90. NVP-AUY922 causes p23 dissociation from the Hsp90 complex and can then recruit HSP70 to the Hsp90 complex. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of Hsp90 to client proteins and setting them up as targets for degradation by the proteasome.NVP-AUY922 can influence cell growth by affecting mutiple signaling pathways.
别名5-[2,4-二羟基-5-异丙基苯基]-N-乙基-4-[4-(4-吗啉基甲基)苯基]-3-异恶唑甲酰胺;AUY922;VER-52296;NVP-AUY 922;AUY-922;VER 52296;VER52296;5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
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