| 溶解性 | DMSO 30 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 备注 | SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc. |
| 生化机理 | VEGFR-3 is a tyrosine kinase receptor recognized by VEGF-C and VEGF-D and plays a major role in lymphangiogenesis. A number of clinical and experimental studies have demonstrated that tumor lymphangiogenesis induced by VEGFR-3 promotes metastasis to regional lymph nodes. SAR131675 is a potent and selective VEGFR-3 inhibitor with antilymphangiogenic, antitumoral, and antimetastatic activities. SAR131675 inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. |
| 别名 | (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide;(R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-ynyl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide |
SAR131675
SAR131675 （订货以英文为准）
编号：S126571
CAS号：1433953-83-3
分子式：C18H22N4O4
分子量：358.39
| 产品名称 | SAR131675 |
| 中文名称 | SAR131675 |
| CAS号 | 1433953-83-3 |
| 分子式（M.F.） | C18H22N4O4 |
| 分子量（M.W.） | 358.39 |
| 储存条件 | -20°C储存 |
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