| 熔点 | 256-271°C |
| 敏感性 | 对光和热敏感 |
| 溶解性 | Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.5480 |
| 应用 | An inhibitor of Ca2+ uptake, 5-LO, and 12-LO |
| 产品介绍 | Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9. |
| 生化机理 | 中药类黄酮的组成成分，黄芩的主要黄酮，抑制花生四烯酸代谢中的12-脂肪氧化酶路径（12-lipoxygenase ，12-LOX），此路径能抑制癌细胞的增殖，诱导凋亡途径。 |
| 别名 | 三羟黄酮;黄芩苷元;黄芩黄素;黄芩甙元;5,6,7-三羟基黄酮;5,6,7-Trihydroxyflavone |
黄芩素
Baicalein （订货以英文为准）
编号：B107324
CAS号：491-67-8
分子式：C15H10O5
分子量：270.24
| 产品名称 | Baicalein |
| 中文名称 | 黄芩素 |
| CAS号 | 491-67-8 |
| 分子式（M.F.） | C15H10O5 |
| 分子量（M.W.） | 270.24 |
| 储存条件 | 2-8°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H302 |
| 个人防护设备 | dust mask type N95 (US),Eyeshields,Gloves |
| RTECS | HP5295050 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R22; |
| 安全声明（欧洲） | S36; |
| 危害码（欧洲） | Xn |
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