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甲苯磺丁脲

Tolbutamide （订货以英文为准）

编号：T129578
CAS号：64-77-7
分子式：C12H18N2O3S
分子量：270.35
货号 品牌 包装 目录价 您的价格 库存 数量 购买
T129578-100g 阿拉丁 100g ¥719.90
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T129578-500g 阿拉丁 500g ¥2799.90
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T129578-25g 阿拉丁 25g ¥199.90
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T129578-5g 阿拉丁 5g ¥61.90
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T129578-10g 阿拉丁 10g ¥102.90
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T129578-250g 阿拉丁 250g ¥1599.90
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T129578-1g 阿拉丁 1g ¥30.00
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产品名称 Tolbutamide
中文名称 甲苯磺丁脲
CAS号 64-77-7
分子式（M.F.） C12H18N2O3S
分子量（M.W.） 270.35
储存条件 -20°C储存
溶解性Soluble in DMSO or 100% ethanol; insoluble in water.
存贮条件储存温度-20°C
产品介绍Tolbutamide is a sulfonylurea agonist for secretion of insulin by beta-cells. In rat pancreatic beta-cells cultured in the presence of Tolbutamide displayed increased numbers of beta-cells in a dose responsive manner with beta-cell numbers doubling at 100 μg/ml of Tolbutamide. The compound displayed inhibitory action towards beta-cells at concentrations greater than 100 μg/ml. In addition in the presence of low glucose concentrations Tolbutamide’s cytotrophic action was inhibited. On isolated dog pancreas islets Tolbutamide at 180 μM stimulated the release of somatostatin, insulin and glucagon in the absence of glucose. in all situations the loss of Ca2+ eliminated all effects of Tolbutamide. The compound has been observed to mechanistically enhance the secretion of insulin by highly selective amplification of insulin secretory burst mass.
别名1-丁基-3-(4-甲苯磺酰基)脲;甲糖宁;1-Butyl-3-(4-methylphenylsulfonyl)urea
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