| 溶解性 | 25°C: DMSO 1mg/mL Water 94 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 产品介绍 | Pemetrexed是抗叶酸和抗代谢剂，对TS，DHFR和GARFT的Ki分别为1.3 nM，7.2 nM和65 nM。 |
| 生化机理 | Description: IC50 Value: 1.3nM(Ki for TS); 7.2nM(DHFR); 65nM(GARFT) Pemetrexed is approved as a first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC) with cisplatin and as a single agent for second-line treatment or for patients who show no disease progression after four cycles of platinum-based doublet induction chemotherapy as maintenance therapy. in vitro: The Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibition against TS, DHFR, and GARFT, respectively. In contrast, although a similar high level of inhibitory potency was observed for the parent monoglutamate against DHFR (7.0 nM), the inhibition constants (Ki) for the parent monoglutamate are significantly weaker for TS (109 nM) and GARFT(9,300 nM).The parent monoglutamate LY231514 inhibited rhTS with a Ki of 109 nM when the monoglutamated form of the substrate (6R-MTHF) (6[R]-5,l0-meth ylenetetrahydrofolate) was used. This is in good agreement with the Ki v |
| 别名 | LY231514;Alimta;LY 231514;LY-231514;培美曲塞酸;LY231514;Alimta;LY 231514;LY-231514 |
培美曲塞
Pemetrexed （订货以英文为准）
编号：P125303
CAS号：137281-23-3
分子式：C20H21N5O6
分子量：427.41
| 产品名称 | Pemetrexed |
| 中文名称 | 培美曲塞 |
| CAS号 | 137281-23-3 |
| 分子式（M.F.） | C20H21N5O6 |
| 分子量（M.W.） | 427.41 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H317-H319 |
| 警示性声明 | P280-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| WGK德国 | 3 |
搜索质检报告(COA)
搜索MSDS
相关产品
¥ 155.00
F903483-100g
¥ 2750.00
sh246789-100kg
¥ 128.00
sh7651-500mL
¥ 128.00
sh8754-500mL
¥ 128.00
sh42798-500mL
¥ 128.00
sh54098-500mL
党沛 
