| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度-20°C |
| 生化机理 | Description:IC50 Value: 5nM [1]AZ20 is a potent and selective inhibitor of ATR with an IC50 value of 5 nM. AZ20 was discovered from a lead discovery and early optimization campaign from an mTOR inhibitor screening hit.in vitro: AZ20 decreases pChk1 Ser345, pChk1 Ser317 and pChk1 Ser296 levels in a concentration-dependent manner. Prolonged exposure with AZ20 increases H2AX pan-nuclear staining, indicative of replication stress [2].in vivo: AZ20 induces significant tumour growth inhibition in vivo at well tolerated doses [2].Clinical trial: N/A |
AZ20,ATR抑制剂
AZ20 （订货以英文为准）
编号：A125603
CAS号：1233339-22-4
分子式：C21H24N4O3S
分子量：412.51
| 产品名称 | AZ20 |
| 中文名称 | AZ20,ATR抑制剂 |
| CAS号 | 1233339-22-4 |
| 分子式（M.F.） | C21H24N4O3S |
| 分子量（M.W.） | 412.51 |
| 储存条件 | -20°C储存 |
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