| 溶解性 | DMSO |
| 存贮条件 | 储存温度2-8℃ |
| 生化机理 | YS-49 is a novel positive inotropic isoquinoline compound. YS-49 has potential as a therapeutic strategy for the pathogenesis of Ang II-related vascular diseases such as hypertension and atherosclerosis, via the induction of HO-1 gene activity. YS-49 induced HO-1 protein production in a dose-and time-dependent manner in VSMCs. Treatment with YS-49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2.YS-49(32.8 microM) exhibited much stronger inhibitory effects on TXA(2) formation. The higher inhibitory potencies of YS-49 (IC(50): 3.3microM) than higenamine (IC(50): 140 microM) on AA induced rat platelet aggregation was presumed to be the result of low inhibitory effect of higenamine than YS-49 on TXA(2) production from AA. The oral administration of YS-49 (50 mg/kg) increased the recovery rates from the acute thrombotic challenge in mice and lowered the weight of thr |
| 别名 | ; |
YS-49,PI3K/Akt激活剂
YS-49 （订货以英文为准）
编号：Y125277
CAS号：132836-42-1
分子式：C20H20BRNO2
分子量：404.30
| 产品名称 | YS-49 |
| 中文名称 | YS-49,PI3K/Akt激活剂 |
| CAS号 | 132836-42-1 |
| 分子式（M.F.） | C20H20BRNO2 |
| 分子量（M.W.） | 404.30 |
| 储存条件 | 2-8°C储存 |
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