AMG-208,C-Met/RON双抑制剂,

AMG-208 (订货以英文为准)

编号:A127592
CAS号:1002304-34-8
分子式:C22H17N5O2
分子量:383.41
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A127592-50mg 阿拉丁 50mg ¥5149.90
A127592-5mg 阿拉丁 5mg ¥699.90
A127592-100mg 阿拉丁 100mg ¥5399.90
A127592-1mg 阿拉丁 1mg ¥299.90
A127592-25mg 阿拉丁 25mg ¥2099.90
A127592-10mg 阿拉丁 10mg ¥1544.90
产品名称 AMG-208
中文名称 AMG-208,C-Met/RON双抑制剂,
CAS号 1002304-34-8
分子式(M.F.) C22H17N5O2
分子量(M.W.) 383.41
储存条件 -20°C储存
溶解性DMSO 0.25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度-20°C
应用A highly selective Met inhibitor (IC50 = 9.3 nM)
产品介绍AMG-208是c-Met抑制剂,IC50为9.3 nM。
备注AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.
生化机理AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor
别名AMG208; AMG 208; 7-甲氧基-4-((6-苯基-1,2,4-三唑并(4,3-b)哒嗪-3-基)甲氧基)喹啉;;AMG208; AMG 208;7-methoxy-4-((6-phenyl-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methoxy)quinoline
搜索质检报告(COA)
搜索MSDS
相关产品
CAS号:7704-98-5
¥ 419.00 T819979-100g
CAS号:7758-02-3
¥ 223.00 P816703-25g
CAS号:288-32-4
¥ 60.00 I811843-25g
CAS号:7791-20-0
¥ 899.00 N814991-5g
CAS号:71-41-0
¥ 115.00 P815993-500ml
CAS号:108-46-3
¥ 225.00 R817303-100g
CAS号:1499-10-1
¥ 556.00 D807000-250mg
CAS号:98-88-4
¥ 258.00 B802234-500g
CAS号:9002-92-0
¥ 520.00 767315-5g