| 溶解性 | DMSO 0.25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 应用 | A highly selective Met inhibitor (IC50 = 9.3 nM) |
| 产品介绍 | AMG-208是c-Met抑制剂，IC50为9.3 nM。 |
| 备注 | AMG 208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1. |
| 生化机理 | AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM . Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent inhibition for CYP3A4 metabolic activity with IC50 of 4.1 μM, which is an eightfold decrease relative to the IC50 (32 μM) without preincubation . AMG-208 is identified to be a c-MET and RON dual selective inhibitor |
| 别名 | AMG208; AMG 208; 7-甲氧基-4-((6-苯基-1,2,4-三唑并(4,3-b)哒嗪-3-基)甲氧基)喹啉;;AMG208; AMG 208;7-methoxy-4-((6-phenyl-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methoxy)quinoline |
AMG-208,C-Met/RON双抑制剂，
AMG-208 （订货以英文为准）
编号：A127592
CAS号：1002304-34-8
分子式：C22H17N5O2
分子量：383.41
| 产品名称 | AMG-208 |
| 中文名称 | AMG-208,C-Met/RON双抑制剂， |
| CAS号 | 1002304-34-8 |
| 分子式（M.F.） | C22H17N5O2 |
| 分子量（M.W.） | 383.41 |
| 储存条件 | -20°C储存 |
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