| 熔点 | 148-151° C |
| 折光率 | 1.70 |
| 溶解性 | DMSO ≥160mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
| 应用 | A selective inhibitor of Bcl-2 |
| 产品介绍 | ABT-737是 Bcl-xL, Bcl-2 和 Bcl-w抑制剂，EC50分别为78.7 nM，30.3 nM和197.8 nM。对Mcl-1， Bcl-B 和 Bfl-1无抑制性。 |
| 备注 | ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2. |
| 生化机理 | ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts. Increased expression of the Bcl-2 family of proteins in cancers has been associated with chemotherapy resistance, inhibiting Bcl-2 or Bcl-XL overexpression could potentially induce apoptosis in cancer cells while having minimal effects on normal cells. |
| 别名 | ABT737;ABT 737; 4-(4-((4'-氯(1,1'-联苯)-2-基)甲基)-1-哌嗪基)-N-((4-(((1R)-3-(二甲基氨基)-1-((苯硫基)甲基)丙基)氨基)-3-硝基苯基)磺酰基)苯甲酰胺;;ABT737;ABT 737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4- (dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl] sulfonylbenzamide |
ABT-737,BH3模拟Bcl-xL，Bcl-2和Bcl-w抑制剂
ABT-737 （订货以英文为准）
编号：A127419
CAS号：852808-04-9
分子式：C42H45CLN6O5S2
分子量：813.43
| 产品名称 | ABT-737 |
| 中文名称 | ABT-737,BH3模拟Bcl-xL，Bcl-2和Bcl-w抑制剂 |
| CAS号 | 852808-04-9 |
| 分子式（M.F.） | C42H45CLN6O5S2 |
| 分子量（M.W.） | 813.43 |
| 储存条件 | -20°C储存 |
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