旋光率 | 18° (C=0.5,2mol/L HCl) |
敏感性 | 热和湿度敏感 |
溶解性 | Soluble in water (50 mg/ml). |
存贮条件 | 储存温度-20°C,充氩保存 |
应用 | A compound shown to increase expression of glutathione peroxidase |
产品介绍 | L-Selenomethionine displays antioxidant activity and has been shown to increase the activity of glutathione peroxidase in endothelial cells. Glutathione peroxidase protects cells from oxidative damage, such as DNA strand breaks, mutations and interference with protein tyrosine-based signaling and other protein functions due to formation of 3-nitrotyrosine, caused by excessive peroxynitrite. L-Selenomethionine administration to cancer cell lines (MCF-7/S breast carcinoma, DU-145 prostate cancer cells and UACC-375 melanoma) results in apoptotic cell death and aberrant mitosis. These human tumor cell lines exhibited dose-dependent growth inhibition by L-Selenomethionine in the micromolar range (45 to 130 μM), while growth inhibition of normal fibroblasts required 1 mM L-Selenomethionine. |
生化机理 | 硒-L-蛋氨酸显示出抗氧化活性,并且已表明能增加内皮细胞中谷胱甘肽过氧化物酶的活性。 谷胱甘肽过氧化物酶保护细胞免受氧化损伤,例如DNA 链断裂、突变和基于蛋白酪氨酸的信号传导的干扰,以及由于过量亚硝酸盐引起的3-硝基酪氨酸形成的其他蛋白质功能。向癌细胞系(MCF-7/S 乳腺癌,DU-145 前列腺癌细胞和UACC-375 黑素瘤)给予硒-L-甲硫氨酸处理,导致细胞凋亡和异常有丝分裂。这些人肿瘤细胞系在微摩尔范围(45至130μM)内表现出硒代蛋氨酸的剂量依赖性生长抑制,而正常成纤维细胞的生长抑制需要 1mM 硒代蛋氨酸。 |
别名 | (S)-2-氨基-4-(甲基硒)丁酸; 硒-L-蛋氨酸; L(+)硒代蛋氨酸;(S)-2-Amino-4-(methylseleno)butyric Acid;Seleno-L-methionine;L(+)-Selenomethionine |
L-硒代蛋氨酸
L-Selenomethionine (订货以英文为准)
编号:S130045
CAS号:3211-76-5
分子式:CH3SECH2CH2CH(NH2)CO2H
分子量:196.11
产品名称 | L-Selenomethionine |
中文名称 | L-硒代蛋氨酸 |
CAS号 | 3211-76-5 |
MDL编码 | MFCD00037210 |
分子式(M.F.) | CH3SECH2CH2CH(NH2)CO2H |
分子量(M.W.) | 196.11 |
储存条件 | -20°C储存;充氩 |
标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
信号词 | Warning |
危害声明 | H302 |
个人防护设备 | dust mask type N95 (US),Eyeshields,Gloves |
RTECS | JW4792000 |
WGK德国 | 3 |
风险声明 (欧洲) | 22 |
安全声明(欧洲) | 36 |
危害码(欧洲) | Xn |
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