| 敏感性 | 易吸湿 |
| 溶解性 | Soluble in ethanol (78 mg/ml at 25 °C), DMF (40 mg/ml), DMSO (100 mg/ml), PBS (pH 7.2) (~0.5 mg/ml), and water (<1 mg/ml at 25 °C), DMSO 25mg/ml Ethanol dimethyl formamide |
| 存贮条件 | 储存温度-20°C |
| 应用 | A highly specific non-competitive inhibitor of NAMPT |
| 产品介绍 | FK866 (APO866, Daporinad)有效抑制烟酰胺磷酸核糖转移酶(NMPRTase)，无细胞试验中IC50为0.09 nM。Phase 1/2。 |
| 备注 | APO866 effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. Phase 1/2. |
| 生化机理 | FK-866 has been shown to induce apoptosis by non-competitive, and specific inhibition of nicotamide phosphoribosyltransferase (NAMPT). NAMPT is a key regulatory enzyme that mediates NAD+ biosynthesis within cells. Mechanistic studies show that this compound contains an enzymatic active site of visfatin which is optimized for nicotinamide binding and inhibition. Visfatin also contains a similar structure to insulin and mimics its actions by binding to the insulin receptors. |
| 别名 | (2E)-N-[4-(1-苯甲酰基-4-哌啶基)丁基]-3-(3-吡啶基)-2-丙烯酰胺;Daporinad; APO866; FK-866; FK 866; APO 866; APO-866;(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide |
FK866 (APO866, Daporinad),NAMPT抑制剂
FK866 (APO866, Daporinad) （订货以英文为准）
编号：F127321
CAS号：658084-64-1
分子式：C24H29N3O2
分子量：391.51
| 产品名称 | FK866 (APO866, Daporinad) |
| 中文名称 | FK866 (APO866, Daporinad),NAMPT抑制剂 |
| CAS号 | 658084-64-1 |
| 分子式（M.F.） | C24H29N3O2 |
| 分子量（M.W.） | 391.51 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg |
| 信号词 | Danger |
| 危害声明 | H301 |
| 警示性声明 | P301 + P310 |
| WGK德国 | 3 |
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