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EI1,EZH2抑制剂

EI1 （订货以英文为准）

编号：E125706
CAS号：1418308-27-6
分子式：C23H26N4O2
分子量：390.48
货号 品牌 包装 目录价 您的价格 库存 数量 购买
E125706-25mg 阿拉丁 25mg ¥918.90
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E125706-5mg 阿拉丁 5mg ¥515.90
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E125706-100mg 阿拉丁 100mg ¥1634.90
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E125706-10mg 阿拉丁 10mg ¥688.90
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E125706-50mg 阿拉丁 50mg ¥1225.90
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产品名称 EI1
中文名称 EI1,EZH2抑制剂
CAS号 1418308-27-6
分子式（M.F.） C23H26N4O2
分子量（M.W.） 390.48
储存条件 避光;-20°C储存
溶解性25°C: DMSO
存贮条件储存温度-20°C
产品介绍EI1是EZH2选择性抑制剂，对野生型EZH2和EZH2 Y641F突变型的IC50分别为15 nM和13 nM。
生化机理EI1 demonstrated potent, concentration-dependent inhibition of the enzymatic activity against both Ezh2 wild-type and Y641F mutant enzymes with IC50 of 15 ± 2 nM and 13 ± 3 nM, respectively. Although SAM is the common cofactor for all HMTs, EI1 showed remarkable selectivity against Ezh2 over other HMTs. EI1 dramatically inhibited the H3K27me3 and H3K27me2 levels in these cells in a dose-dependent manner, but H3K27me1 was largely unchanged. The effect was similar in these cell lines, although they have different basal H3K27me3 and H3K27me2 levels. For example, in WSU-DLCL2, SU-DHL6, and Karpas422 with Ezh2 mutations, the H3K27me3 level was much higher than that in DLBCL cells with wild-type Ezh2
别名EI-1;EI 1;6-氰基-N-[(1,2-二氢-4,6-二甲基-2-氧代-3-吡啶基)甲基]-1-(1-乙基丙基)-1H-吲哚-4-甲酰胺;Ezh2 inhibitor；6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide
搜索质检报告(COA)
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