| 敏感性 | 对热和光线敏感 |
| 溶解性 | Soluble in methanol, ethanol (0.1 mg/ml), DMSO (0.1 mg/ml), acetone, and chloroform. Insoluble in water., |
| 存贮条件 | 储存温度: -20 ℃;充氩保存 |
| 密度 | 1.1200 |
| 应用 | A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase |
| 产品介绍 | Bafilomycin A1 is a potent and selective inhibitor of V-ATPase (vacuolar-type (v-type) H+ ATPase) and belongs to a class of membrane ATPase inhibitors. The compound can inhibit E1E2 ATPases from sarcoplasmic reticulum, Escherichia coli, and ox brain versus F1F0 ATPases found in bacteria and mitochondria. Some of the more bafilomycin A1 affected ATPases include Neurospora and plant vacuoles, as well as chromaffin granules. Additionally, Bafilomycin A1 prevents lysosomal cholesterol trafficking in macrophages and can be used to distinguish different types of ATPases. Research shows that Bafilomycin A1 can inhibit macroautophagy and promote apoptosis in colon cancer cells. |
| 生化机理 | 动物细胞、植物细胞和微生物液泡型H+-ATP酶（V-ATP酶）的特异性抑制剂。 |
| 别名 | ; |
巴佛洛霉素A1
Bafilomycin A1 （订货以英文为准）
编号：B101389
CAS号：88899-55-2
分子式：C35H58O9
分子量：622.83
| 产品名称 | Bafilomycin A1 |
| 中文名称 | 巴佛洛霉素A1 |
| CAS号 | 88899-55-2 |
| 分子式（M.F.） | C35H58O9 |
| 分子量（M.W.） | 622.83 |
| 储存条件 | -20°C储存;充氩 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs06.jpg,https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H300,H350 |
| 警示性声明 | P201,P264,P301+P310,P308+P313 |
| 个人防护设备 | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
| RTECS | SZ2975000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R45;R46;R28 |
| 安全声明（欧洲） | S53;S22;S26;S36/37/39;S45 |
| 危害码（欧洲） | T+ |
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