| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (≥20 mg/ml at 25 °C), methanol (10 mg/ml), chloroform (10 mg/ml yielding a clear purple solution), water (<1 mg/ml at 25 °C), and ethanol (≥5 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 -20°C |
| 应用 | A potent Hsp90 inhibitor for tumor cells |
| 产品介绍 | 17-AAG (Tanespimycin)是一种有效的HSP90抑制剂，IC50为5 nM，作用于从肿瘤细胞提取的HSP90比作用于从正常细胞提取的HSP90结合亲和力高100倍。 |
| 生化机理 | 17-AAG is a less toxic and more stable analog of geldanamycin. It acts an Hsp90 inhibitor that displays a 100-fold higher affinity for Hsp90 derived from tumor cells compared to Hsp90 from normal cells. 17-AAG inhibits Akt1 (Akt) activation and expression in tumors and synergizes with a number of anti tumor agents such as taxol2, cisplatin3, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α5. 17-AAG is an inhibitor of K-Ras and N-Ras. |
| 别名 | 替拉替尼Telatinib;Tanespimycin;KOS 953;NSC 330507;Tanespimycin;CP 127374;BMS 722782;17-(Allylamino)-17-demethoxygeldanamycin;17-(Allylamino)geldanamycin;17-Demethoxy-17-allylamino geldanamycin;Geldanamycin |
17-AAG,HSP90抑制剂
17-AAG （订货以英文为准）
编号：A126970
CAS号：75747-14-7
分子式：C31H43N3O8
分子量：585.69
| 产品名称 | 17-AAG |
| 中文名称 | 17-AAG,HSP90抑制剂 |
| CAS号 | 75747-14-7 |
| MDL编码 | MFCD04973892 |
| 分子式（M.F.） | C31H43N3O8 |
| 分子量（M.W.） | 585.69 |
| 储存条件 | -20°C储存 |
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