| 别名 | ; |
2,4-二甲氧基肉桂酸
2,4-Dimethoxycinnamic Acid （订货以英文为准）
编号：D155055
CAS号：6972-61-8
分子式：C11H12O4
分子量：208.21
| 产品名称 | 2,4-Dimethoxycinnamic Acid |
| 中文名称 | 2,4-二甲氧基肉桂酸 |
| CAS号 | 6972-61-8 |
| MDL编码 | D155055 |
| 分子式（M.F.） | C11H12O4 |
| 分子量（M.W.） | 208.21 |
| Reaxys-RN | 2854677 |
| 信号词 | Warning |
| 危害声明 | H315-H319-H335 |
| 警示性声明 | P261-P305 + P351 + P338 |
| 个人防护设备 | dust mask type N95 (US)， Eyeshields， Gloves |
| WGK德国 | 3 |
技术规格
| Background: | Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. |
| Applications: | WB, IHC |
| Name of antibody: | CHUK (Phospho-Thr23) |
| Immunogen: | Synthetic peptide of human CHUK (Phospho-Thr23) |
| Full name: | conserved helix-loop-helix ubiquitous kinase (Phospho-Thr23) |
| Synonyms： | IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha |
| SwissProt: | O15111 |
| IHC positive control: | Human colon carcinoma |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 85 kDa |
| WB Positive control: | 293 cells untreated or treated with TNF |
| WB Recommended dilution: | 500-1000 |
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