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Genz-644282,Topo I 抑制剂

Genz-644282 （订货以英文为准）

编号：G126864
CAS号：529488-28-6
分子式：C22H21N3O5
分子量：407.42
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G126864-5mg 阿拉丁 5mg ¥1010.90
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G126864-25mg 阿拉丁 25mg ¥3707.90
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G126864-10mg 阿拉丁 10mg ¥1853.90
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G126864-100mg 阿拉丁 100mg ¥8374.90
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G126864-50mg 阿拉丁 50mg ¥4632.90
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产品名称 Genz-644282
中文名称 Genz-644282,Topo I 抑制剂
CAS号 529488-28-6
分子式（M.F.） C22H21N3O5
分子量（M.W.） 407.42
储存条件 -20°C储存
沸点~665.5 °C at 760 mmHg
熔点>240 °C
折光率1.65
溶解性25°C: DMSO
存贮条件储存温度-20°C
密度1.3000
产品介绍Genz-644282是非喜树碱类拓扑异构酶I抑制剂，IC50为1.2 nM，有抗肿瘤活性。
生化机理Description:IC50 Value: 1.2 nM [1]Genz-644282 [8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate of non-Camptothecin topoisomerase I inhibitor for antitumor agents.in vitro: Genz-644282 demonstrated potent cytotoxic activity with a median IC(50) of 1.2?nM (range 0.2-21.9?nM) [1]. Limited cross-resistance to Genz-644282 was also found in the Top1 knockdown colon cancer (HCT116) and breast cancer (MCF7) cell lines and in human adenocarcinoma cells (KB31/KBV1) that overexpress (P-glycoprotein, ABCB1), a member of the ATP-binding cassette family of cell surface transport proteins known to confer MDR [3].in vivo: Genz-644282 at its MTD (4?mg/kg) induced maintained complete responses (MCR) in 6/6 evaluable solid tumor models. At 2?mg/kg Genz-644282 induced CR or MCR in 3/3 tumor models relatively insensitive to topotecan, but there were no objective responses at 1?mg/
别名Genz644282;Genz 644282;Genz644282;Genz 644282；2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one
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