| 溶解性 | DMSO 65 mg/mL Water <1 mg/mL Ethanol 32 mg/mL |
| 应用 | Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors. |
| 产品介绍 | Clozapine 是一种有效的5-HT1C受体拮抗剂，作用于5-HT刺激的磷酸肌醇水解，IC50为110 nM。 |
| 备注 | Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| 生化机理 | Clozapine is atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Clozapine displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively). |
| 别名 | 8-氯-11-(4-甲基-1-哌嗪基)-5H-二苯并[b,e][1,4]-二氮杂草;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
氯氮平
Clozapine （订货以英文为准）
编号：C126883
CAS号：5786-21-0
分子式：C18H19CLN4
分子量：326.82
| 产品名称 | Clozapine |
| 中文名称 | 氯氮平 |
| CAS号 | 5786-21-0 |
| 分子式（M.F.） | C18H19CLN4 |
| 分子量（M.W.） | 326.82 |
| 储存条件 | 2-8°C储存 |
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