BMS-663068,是 BMS626529 的膦酰氧甲基前药

BMS-663068 (订货以英文为准)

编号:B127031
CAS号:864953-29-7
分子式:C25H26N7O8P
分子量:583.49
货号 品牌 包装 目录价 您的价格 库存 数量 购买
B127031-5mg 阿拉丁 5mg ¥1853.90
B127031-10mg 阿拉丁 10mg ¥2969.90
B127031-25mg 阿拉丁 25mg ¥6179.90
B127031-50mg 阿拉丁 50mg ¥9269.90
产品名称 BMS-663068
中文名称 BMS-663068,是 BMS626529 的膦酰氧甲基前药
CAS号 864953-29-7
分子式(M.F.) C25H26N7O8P
分子量(M.W.) 583.49
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度-20°C
生化机理BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. BMS-663068 is a prodrug for BMS-626529 which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Administration of BMS-663068 for 8 days with or without ritonavir resulted in substantial declines in plasma HIV-1 RNA levels and was generally well tolerated. Longer-term clinical trials of BMS-663068 as part of combination antiretroviral therapy are warranted.
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