| 溶解性 | DMSO 104 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.6000 |
| 应用 | A highly potent, ATP-competitive, and specific mTOR kinase inhibitor |
| 产品介绍 | WYE-125132是ATP竞争性mTOR选择性抑制剂，IC50为0.19 nM，对PI3Ks及其相关的hSMG1和ATR抑制性较弱。 |
| 生化机理 | WYE-125132 is a potent, ATP-competitive inhibitor of recombinant mTOR kinase,with an IC50 of 0.19 nM. WYE-125132 shows an anti-proliferative activity against a variety of tumor cell lines with IC50 ranging from 2 nM (LNCap) to 380 nM (HTC116), in vitro. WYE-125132 causes inhibition of protein synthesis and cell size, induction of apoptosis, and cell cycle progression. WYE-125132 causes pre-tRNA Leu synthesis reduction by 72%, 80%, and 53% in actively proliferating cells of MG63, MDA361, and HEK293, respectively as a result of the inhibition of mTORC1. WYE-125132 induces Maf1 dephosphorylation and its accumulation in the nucleus. |
| 别名 | WYE-125132；WYE 125132; WYE125132；WYE 125132; N-[4-[1-(1,4-二氧杂螺[4.5]癸烷-8-基)-4-(8-氧杂-3-氮杂双环[3.2.1]辛烷-3-基)-1H-吡唑并[3,4-d]嘧啶-6-基]苯基]-N'-甲基脲;WYE-125132；WYE 125132;WYE125132；N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea |
WYE-125132(WYE-132),ATP竞争性mTOR抑制剂
WYE-125132 (WYE-132) （订货以英文为准）
编号：W128041
CAS号：1144068-46-1
分子式：C27H33N7O4
分子量：519.61
| 产品名称 | WYE-125132 (WYE-132) |
| 中文名称 | WYE-125132(WYE-132),ATP竞争性mTOR抑制剂 |
| CAS号 | 1144068-46-1 |
| 分子式（M.F.） | C27H33N7O4 |
| 分子量（M.W.） | 519.61 |
| 储存条件 | -20°C储存 |
搜索质检报告(COA)
搜索MSDS
相关产品
党沛 
