2-甲氧基雌二醇

2-Methoxyestradiol (2-MeOE2) (订货以英文为准)

编号:M125960
CAS号:362-07-2
分子式:C19H26O3
分子量:302.41
货号 品牌 包装 目录价 您的价格 库存 数量 购买
M125960-50mg 阿拉丁 50mg ¥442.90
M125960-10mg 阿拉丁 10mg ¥144.90
M125960-500mg 阿拉丁 500mg ¥2805.00
M125960-25mg 阿拉丁 25mg ¥258.90
M125960-100mg 阿拉丁 100mg ¥797.90
产品名称 2-Methoxyestradiol (2-MeOE2)
中文名称 2-甲氧基雌二醇
CAS号 362-07-2
分子式(M.F.) C19H26O3
分子量(M.W.) 302.41
储存条件 -20°C储存
溶解性Soluble in DMSO (10 mg/mL), ethanol (10 mg/mL), chloroform, ethanol (1 mg/ml), and 1:1DMF:PBS(pH7.2) (0.5 mg/ml). Insoluble in water.
应用A disruptor of microtubule function and HIF-1 inhibitor
产品介绍2-Methoxyestradiol (2-MeOE2)使微管解聚,且抑制HIF-1α核积累和HIF转录活性。Phase 2。
备注2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.
生化机理2-methoxyestradiol (2ME2) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 ± 0.11 μM for the inhibition of BPAEC migration.2-Methoxyestradiol is an endogenous estrogen metabolite with low affinity for the estrogen receptor but which disrupts microtubule function. 2-Methoxyestradiol is formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. 2-Methoxyestradiol is a derivative of an oestrogenic steroidal hormone and has demonstrated: potent inhibition of endothelial cell proliferation and migration and inhibition of bFGF and VEGF-induced corneal neovascularization in mice. In MDA-MB-231 cells, 2-Methoxyestradiol inhibits HIF mediated transcriptional activation of target genes without affecting the transcription of HIF-1α itself. 2-Methoxyestradiol has been shown to induce apoptosis through activation of the p53 pathway through either activation of p38 and NF-κ
别名2-MeOE2;2-甲氧基-β-雌二醇;2-甲氧基雌二醇;2-ME2;(8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol;2-Methoxy-β-estradiol
搜索质检报告(COA)
搜索MSDS
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