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GW1929,PPARγ激动剂

GW1929 （订货以英文为准）

编号：G125821
CAS号：196808-24-9
分子式：C30H29N3O4
分子量：495.57
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G125821-10mg 阿拉丁 10mg ¥1298.90
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G125821-50mg 阿拉丁 50mg ¥5843.90
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G125821-5mg 阿拉丁 5mg ¥703.90
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产品名称 GW1929
中文名称 GW1929,PPARγ激动剂
CAS号 196808-24-9
分子式（M.F.） C30H29N3O4
分子量（M.W.） 495.57
储存条件 2-8°C储存
溶解性25°C: DMSO
存贮条件储存温度2-8℃
生化机理Description:IC50 Value: 5.0±0.7 mumol/l [1].GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist,in vitro: Using Ba2+ (10 mmol/l) as the charge carrier through VDCC, the half-inhibition constants (IC50) for GI 262570, GW 7845, GW 1929, and pioglitazone were 2.0 +/- 0.5, 3.0 +/- 0.5, 5.0 +/- 0.7, and 10.0 +/- 0.8 mumol/l, respectively [1]. PPARγ agonist GW1929significantly decreased TRPC1 and TRPC6 expression in PASMCs [2].in vivo: GW1929treatment significantly attenuated the neurological damage in focal cerebral IR injury. Neuroprotective effects of GW1929 were found to be associated with significant reduction in the COX-2, iNOS, MMP-9, TNFα and IL-6 levels [3].GW1929treatment significantly ameliorated cerebral IR induced neurological symptoms, hyperlocomotion, cognitive deficits and hippocampal neuronal damage in CA1 hippocampus region in gerbils. Significant reduction in IR injury in
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