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Bardoxolone,诱导剂

Bardoxolone （订货以英文为准）

编号：B125862
CAS号：218600-44-3
分子式：C31H41NO4
分子量：491.66
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B125862-100mg 阿拉丁 100mg ¥3591.90
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B125862-25mg 阿拉丁 25mg ¥1566.90
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产品名称 Bardoxolone
中文名称 Bardoxolone,诱导剂
CAS号 218600-44-3
分子式（M.F.） C31H41NO4
分子量（M.W.） 491.66
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度-20°C
产品介绍Bardoxolone(RTA 402)是抗氧化炎症调节剂（AIM）的先导化合物，此类AIM是转录因子Nrf2诱导剂。
生化机理Bardoxolone methyl, previously known as RTA 402, is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. Because oxidative stress and inflammation occur throughout the course of chronic kidney disease (CKD) and are known to contribute to loss of kidney function, agents that activate the Nrf2 pathway in patients with CKD may provide a novel method for preserving or improving kidney function. Bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for CKD.
别名CDDO;RTA 401;RTA401;RTA-401;2-氰基-3,12-二氧代齐墩果-1,9-二烯-28-酸;CDDO;RTA 401;RTA401;RTA-401;2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
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