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CGK 733,ATR和ATM激酶抑制剂

CGK 733 （订货以英文为准）

编号：C129735
CAS号：905973-89-9
分子式：C23H18CL3FN4O3S
分子量：555.84
货号 品牌 包装 目录价 您的价格 库存 数量 购买
C129735-5mg 阿拉丁 5mg ¥267.90
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C129735-10mg 阿拉丁 10mg ¥411.90
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C129735-50mg 阿拉丁 50mg ¥1441.90
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产品名称 CGK 733
中文名称 CGK 733,ATR和ATM激酶抑制剂
CAS号 905973-89-9
分子式（M.F.） C23H18CL3FN4O3S
分子量（M.W.） 555.84
储存条件 2-8°C储存
溶解性DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
存贮条件储存温度 2-8°C
应用A cell-permeable compound that inhibits kinase activity of ATM / ATR (RETRACTED).
产品介绍CGK 733是一种有效的ATM/ATR选择性抑制剂，IC50约为200 nM。
备注CGK 733 is a potent and selective inhibitor of ATM/ATR with IC50 of ~200 nM.
生化机理ATM/ATR Kinase Inhibitor (CGK733) Was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC50 ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product we retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated
别名alpha-苯基-N-[2,2,2-三氯-1-[[[(4-氟-3-硝基苯基)氨基]硫代甲酰]氨基]乙基]-苯乙酰胺CGK-733;ATM/ATR Kinase Inhibitor;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide
标识符号https://www.aladdin-e.com/images/ghs/ghs07.jpg
信号词Warning
危害声明H315-H319-H335
警示性声明P261-P305 + P351 + P338
个人防护设备dust mask type N95 (US), Eyeshields, Gloves
WGK德国3
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