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RITA (NSC 652287),p53激活剂

RITA (NSC 652287) （订货以英文为准）

编号：R125421
CAS号：213261-59-7
分子式：C14H12O3S2
分子量：292.37
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R125421-50mg 阿拉丁 50mg ¥3831.90
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R125421-10mg 阿拉丁 10mg ¥1092.90
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R125421-5mg 阿拉丁 5mg ¥672.90
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产品名称 RITA (NSC 652287)
中文名称 RITA (NSC 652287),p53激活剂
CAS号 213261-59-7
分子式（M.F.） C14H12O3S2
分子量（M.W.） 292.37
储存条件 -20°C储存
溶解性Soluble in DMSO (58 mg/ml at 25 °C), ethanol (8 mg/ml at 25 °C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25 °C).
存贮条件储存温度-20°C
应用A trycyclic thiophene derivative that binds MDM2, activates p53 and induces apoptosis.
产品介绍RITA (NSC 652287)诱导DNA-蛋白质和DNA-DNA交联，检测不到DNA单链断裂，通过靶向作用于p53，也抑制MDM2-p53相互作用。
备注RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.
生化机理p53 Activator III, RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Renal carcinoma research has demonstrated that RITA induces DNA damage, and DNA-DNA, DNA-protein crosslinks. Furthermore, low concentrations of RITA caused cell cycle arrest in G0-G1 and G2-M, and elevated p53 and p21(WAF1) protein levels in renal carcinoma studies. At higher concentrations RITA has been reported to cause an increases of p53 protein levels, reduces p21(WAF1) protein levels, and induce apoptosis.
别名SOS BISMETHANOL;2-Thiophenemethanol, 5,5'-(2,5-furandiyl)bis-;NSC 652287;NSC-652287;NSC652287;5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
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