| 溶解性 | Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~2 mg/ml), 1:1 solution of DMSO:PBS(PH7.2) (~0.5 mg/ml), and water (<1 mg/ml) at 25 °C. |
| 存贮条件 | 储存温度-20°C |
| 应用 | An HDAC inhibitor shown to inhibit angiogenesis and metastasis. |
| 产品介绍 | Entinostat (MS-275)对HDAC1和HDAC3抑制作用强于与HDACs 4， 6， 8，和10，IC50分别为0.51 μM和1.7 μM。 |
| 备注 | Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2. |
| 生化机理 | MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, MS-275 does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin, inhibitors of poly (ADP-ribose) polymerase (PARP), or inhibitors of heat shock protein 90 (Hsp90). |
| 别名 | SNDX-275;恩替诺特; N-[[4-[[(2-氨基苯基)氨基]甲酰]苯基]甲基]氨基甲酸 3-吡啶基甲基酯;MS-275; SNDX-275; MS 275; SNDX 275;A HDAC1 and HDAC3 inhibitor;3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate; N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide |
恩替诺特 (MS-275)
Entinostat (MS-275) （订货以英文为准）
编号：E125068
CAS号：209783-80-2
分子式：C21H20N4O3
分子量：376.41
| 产品名称 | Entinostat (MS-275) |
| 中文名称 | 恩替诺特 (MS-275) |
| CAS号 | 209783-80-2 |
| MDL编码 | MFCD03453552 |
| 分子式（M.F.） | C21H20N4O3 |
| 分子量（M.W.） | 376.41 |
| 储存条件 | -20°C储存 |
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