| 熔点 | 250°C(dec.)(lit.) |
| 溶解性 | Soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A nucleoside analog structurally related to Acyclovir. |
| 产品介绍 | Ganciclovir 是一种抗病毒药，作用于猫科动物1型疱疹病毒，IC50为5.2 μM。 |
| 备注 | Ganciclovir is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM. |
| 生化机理 | Ganciclovir is a nucleoside analog structurally related to Acyclovir that acts as a prodrug activated by phosphorylation. Ganciclovir has been used in the study of “suicide” gene therapy in cancer research, where upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Ganciclovir has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents. |
| 别名 | 更昔洛韦;9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤;BW 759; 2'-Nor-2'-deoxyguanosine;2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2'-NDG; |
更昔洛韦 水合物
Ganciclovir （订货以英文为准）
编号：G129109
CAS号：82410-32-0
分子式：C9H13N5O4
分子量：255.23
| 产品名称 | Ganciclovir |
| 中文名称 | 更昔洛韦 水合物 |
| CAS号 | 82410-32-0 |
| MDL编码 | MFCD00870588 |
| 分子式（M.F.） | C9H13N5O4 |
| 分子量（M.W.） | 255.23 |
| 储存条件 | 2-8°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Danger |
| 危害声明 | H317,H334 |
| 警示性声明 | P261,P280,P342+P311 |
| WGK德国 | 2 |
| 风险声明 (欧洲) | R42/43; |
| 安全声明（欧洲） | S23///;S36/37;S45; |
| 危害码（欧洲） | Xn |
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