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DAPT,γ-分泌酶抑制剂

DAPT （订货以英文为准）

编号：D126677
CAS号：208255-80-5
分子式：C23H26F2N2O4
分子量：432.46
货号 品牌 包装 目录价 您的价格 库存 数量 购买
D126677-50mg 阿拉丁 50mg ¥344.90
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D126677-5mg 阿拉丁 5mg ¥60.00
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D126677-25mg 阿拉丁 25mg ¥215.90
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D126677-10mg 阿拉丁 10mg ¥113.90
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D126677-1g 阿拉丁 1g ¥2885.90
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D126677-250mg 阿拉丁 250mg ¥1130.90
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产品名称 DAPT
中文名称 DAPT,γ-分泌酶抑制剂
CAS号 208255-80-5
MDL编码 MFCD04974585
分子式（M.F.） C23H26F2N2O4
分子量（M.W.） 432.46
储存条件 2-8°C储存;充氩
敏感性对热敏感
溶解性Soluble in DMSO (15 mg/mL), ethanol (~1 mg/mL), dichloromethane, DMF (~25 mg/mL), and 1:9 solution of DMF:PBS(pH 7.2) (~0.1 mg/mL).
存贮条件储存温度2-8°C
应用A potent and specific inhibitor of γ-secretase.
产品介绍DAPT (GSI-IX)是一种新型γ-分泌酶抑制剂，抑制HEK 293细胞中全部Aβ产量， IC50为20 nM。
备注DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
生化机理DAPT is a potent and specific inhibitor of γ-secretase. It has been shown to cause a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ40 and Aβ42 respectively). There is evidence that DAPT does not effect APPα and APPβ levels. It mimics notch signaling deficiencies at morphological, molecular and biochemical levels and has been shown to block notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC).
别名GSI-IX;(3,5-二氟苯乙酰基)-Ala-Phg-OtBu;(3,5-二氟苯乙酰基)-L-丙氨酰基-L-2-苯基甘氨酸叔丁酯;GSI-IX;GSI IX;γ-Secretase Inhibitor IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;(3,5-Difluorophenylacetyl)-L-alanyl-L-2-phenylglycine tert-Butyl Ester;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu
搜索质检报告(COA)
搜索MSDS
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