| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO |
| 存贮条件 | 储存温度:-20℃ |
| 密度 | 1.0720 |
| 应用 | Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins. |
| 产品介绍 | Leptomycin B is an anti-fungal antibiotic, anti-tumor cytotoxin that inhibits CRM1-dependent, NES-dependent nucleo-cytoplasmic translocation (nuclear export inhibitor). NES containing proteins include HIV-1 REV; actin, c-Abl, cyclin B1, MDM2/p53, IB, MPF, PKA and MEK. |
| 生化机理 | Leptomycin B is an unsaturated, branched-chain fatty acid, and is an important tool in the study of nuclear export. It is a specific inhibitor of proteins containing nuclear export signal. It inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. The addition of very small amounts to fibroblasts causes accumulation of MEK in the nucleus. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, IκB, MPF, and PKA. The suggested inhibition mechanism involves the direct binding of leptomycin B to CRM1, which blocks the binding of CRM1 to proteins containing the nuclear export signal, via the interaction with cysteine residue in CRM1 control conserved region. |
| 别名 | ;Mantuamycin; LMB; Elactocin |
来普霉素B
Leptomycin B （订货以英文为准）
编号：L102387
CAS号：87081-35-4
分子式：C33H48O6
分子量：540.73
| 产品名称 | Leptomycin B |
| 中文名称 | 来普霉素B |
| CAS号 | 87081-35-4 |
| MDL编码 | MFCD06795848 |
| 分子式（M.F.） | C33H48O6 |
| 分子量（M.W.） | 540.73 |
| 储存条件 | 避光;-20°C储存;充氩 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs05.jpg |
| 信号词 | Danger |
| 危害声明 | H315,H318 |
| 警示性声明 | P280,P305+P351+P338 |
| 个人防护设备 | dust mask type N95 (US), Eyeshields, Gloves |
| RTECS | OD2800000 |
| WGK德国 | 1 |
| 闪点（摄氏） | 110 °C |
| 风险声明 (欧洲) | R38;R41 |
| 安全声明（欧洲） | S26;S39 |
| 危害码（欧洲） | Xi |
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