来曲唑

Letrozole (订货以英文为准)

编号:L129473
CAS号:112809-51-5
分子式:C17H11N5
分子量:285.30
货号 品牌 包装 目录价 您的价格 库存 数量 购买
L129473-25mg 阿拉丁 25mg ¥199.00
L129473-5g 阿拉丁 5g ¥276.90
L129473-1g 阿拉丁 1g ¥93.90
L129473-500mg 阿拉丁 500mg ¥1699.00
L129473-100mg 阿拉丁 100mg ¥499.00
L129473-100g 阿拉丁 100g ¥2587.90
L129473-25g 阿拉丁 25g ¥882.90
产品名称 Letrozole
中文名称 来曲唑
CAS号 112809-51-5
分子式(M.F.) C17H11N5
分子量(M.W.) 285.30
储存条件 -20°C储存
存贮条件储存温度-20°C
应用Letrozole has been used:· in organoid growth assay to determine its inhibitory capacity(48)· to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49)· to determine its effects on tumor-induced hyperalgesia(50)· for hormonal manipulation in rats(51)· to study its effects on lipocalin-2 (Lcn2)(52)· to determine its effects on mechanical hyperalgesia and aromatase expression(53)
产品介绍Letrozole是非甾体类芳香酶抑制剂,其 IC50 为1-13 nM;是第三代aromatase抑制剂,无细胞试验中IC50为0.07-20 nM。在临床研究中,对17α-OH progesterone、TSH、促黄体激素、促卵泡激素或雄烯二酮的血浆浓度没有作用,不影响正常的尿电解质排泄或甲状腺功能。
生化机理Letrozole acts as an adjuvant agent and is used to treat breast cancer. Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.
别名来曲唑;Femara, Piroxicam; 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
RTECSDI4957000
WGK德国3
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