概述
Fusion protein corresponding to a region derived from 731-930 amino acids of human ABI3BP
技术规格
| Full name: | ABI family, member 3 (NESH) binding protein |
| Synonyms: | TARSH; NESHBP |
| Swissprot: | Q7Z7G0 |
| Gene Accession: | BC030221 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | A target of NESH-SH3/Abi3bp (TARSH) was originally identified as an SH3 domain-binding molecule of the NESH-SH3/Abi3 protein that is involved in Rac-dependent actin polymerization. In recent studies, TARSH gene expression was dramatically induced in mouse embryonic fibroblasts (MEFs) replicative senescence and suppressed in human lung carcinoma specimens and thyroid carcinomas. However, the molecular mechanism underlying the regulation of TARSH in tumorigenesis remains unclear. |
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