概述
Fusion protein corresponding to a region derived from 26-207 amino acids of human CALD1
技术规格
| Full name: | caldesmon 1 |
| Synonyms: | CDM, HCAD, LCAD, H-CAD, L-CAD, NAG22 |
| Swissprot: | Q05682 |
| Gene Accession: | BC040354 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | Escherichia coli |
| Tags: | His tag C-Terminus, GST tag N-Terminus |
| Background: | This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
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