| 应用 | A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In heart, it increases contractile force and action potential duration, and shows an anti-β-adrenergic effect. |
| 别名 | 磷酸二腺苷（as trilithium tetrahydrate）;Diadenosine pentaphosphate （as trilithium tetrahydrate） |
磷酸二腺苷（as trilithium tetrahydrate）
Diadenosine pentaphosphate （as trilithium tetrahydrate） （订货以英文为准）
编号：D197212
CAS号：75522-97-3
分子式：C20H24N10O22P5-5.5[LI+]
分子量：946.03
| 产品名称 | Diadenosine pentaphosphate （as trilithium tetrahydrate） |
| 中文名称 | 磷酸二腺苷（as trilithium tetrahydrate） |
| CAS号 | 75522-97-3 |
| 分子式（M.F.） | C20H24N10O22P5-5.5[LI+] |
| 分子量（M.W.） | 946.03 |
| 储存条件 | -20°C储存 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs08.jpg |
| 信号词 | Warning |
| 危害声明 | H316,H361 |
| 警示性声明 | P201,P202,P208,P308+P313,P332+P313,P405,P501 |
| RTECS | AU6200000 |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R63 |
| 安全声明（欧洲） | S36/37;S60 |
| 危害码（欧洲） | Xn |
技术规格
| Background: | This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. |
| Applications: | WB, IHC |
| Name of antibody: | AIFM1 |
| Immunogen: | Fusion protein of human AIFM1 |
| Full name: | apoptosis inducing factor mitochondria associated 1 |
| Synonyms: | AIF; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6 |
| SwissProt: | O95831 |
| IHC positive control: | Human colorectal cancer and Human kidney tissue; Human liver tissue and Human pancreas tissue |
| IHC Recommend dilution: | 200-500 |
| WB Predicted band size: | 67 KD |
| WB Positive control: | K562, HepG2, Hela, 293T, A431, Raji cell, Mouse liver tissue lysates |
| WB Recommended dilution: | 500-2000 |
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