A66,PI 3-激酶p110α抑制剂

A66 (订货以英文为准)

编号:A128051
CAS号:1166227-08-2
分子式:C17H23N5O2S2
分子量:393.53
货号 品牌 包装 目录价 您的价格 库存 数量 购买
A128051-50mg 阿拉丁 50mg ¥2326.90
A128051-10mg 阿拉丁 10mg ¥784.90
A128051-1mg 阿拉丁 1mg ¥217.90
A128051-5mg 阿拉丁 5mg ¥490.90
A128051-100mg 阿拉丁 100mg ¥3721.90
A128051-25mg 阿拉丁 25mg ¥1454.90
产品名称 A66
中文名称 A66,PI 3-激酶p110α抑制剂
CAS号 1166227-08-2
MDL编码 MFCD22378485
分子式(M.F.) C17H23N5O2S2
分子量(M.W.) 393.53
储存条件 -20°C储存
溶解性DMSO 79 mg/mL Water <1 mg/mL Ethanol 1 mg/mL
存贮条件储存温度-20°C
备注A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms.
生化机理A66 is a highly specific and selective p110α inhibitor with IC50 of 32,30 and 43 nM for p110α, p110α/E545K, p110α/H1047R, respectively. A66 S potently blocks phosphorylation of Akt/PKB in a subgroup of the cell lines tested demonstrates that some cell types are highly dependent on p110α activity. A66 is more than 100 fold less active against the other class-I PI 3-kinase isoforms and had not inhibitory activity against 200 protein kinases when tested at 10 micromolar. This makes it the most selective and specific p110alpha inhibitor available for research purposes. A66 S is more efficacious at inducing growth delay in HCT116. While A66 S did not induce tumor regression in xenograft models the ability to induce growth delay indicates p110α selective have to ability to be effective as cytostatic agents in some tumor types.
别名(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide
搜索质检报告(COA)
搜索MSDS
相关产品
CAS号:252917-06-9
¥ 113.90 C125082-5mg
CAS号:252935-94-7
¥ 817.90 C129718-5mg
CAS号:252917-06-9
¥ 502.90 C129710-5mg
CAS号:1217486-61-7
¥ 124.90 B127311-1mg
CAS号:371935-74-9
¥ 707.90 P125961-10mg
CAS号:1173900-33-8
¥ 768.90 A129523-5mg
CAS号:900185-02-6
¥ 283.90 P129553-1mg
CAS号:915019-65-7
¥ 308.90 B126286-25mg