概述
Fusion protein corresponding to a region derived from 18-740 amino acids of human ACE2
技术规格
| Full name: | angiotensin I converting enzyme 2 |
| Synonyms: | ACEH |
| Swissprot: | Q9BYF1 |
| Purity: | >95%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | HEK293 |
| Tags: | mFc Tag C-terminals |
| Species: | Human |
| Molecular mass: | 109.7 kDa |
| Research areas: | Microbiology |
| Background: | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2 (COVID-19 virus). |
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