兔抗ACER1多克隆抗体

产品编号：D161416 品牌：BBI

产品特点：

技术规格

Background:	Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).
Applications:	ELISA, IHC
Name of antibody:	ACER1
Immunogen:	Synthetic peptide of human ACER1
Full name:	alkaline ceramidase 1
Synonyms:	ASAH3; ALKCDase1
SwissProt:	Q8TDN7
ELISA Recommended dilution:	5000-10000
IHC positive control:	Human liver cancer and human brain
IHC Recommend dilution:	25-100