熔点 | 277-280°C |
溶解性 | Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM). |
应用 | 一个具有抗菌,消炎,抗氧化性能的天然产物。有抑制肿瘤细胞株扩增和促凋亡作用。A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor |
产品介绍 | Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2.Isolated from the leaves and stems of Macleaya cordata and M. microcarpa. |
备注 | CAS Number: 5578-73-4 (anhydrous),Formula weight and CAS # are for anhydrous basis. |
别名 | 氯化血根碱;血根碱盐酸盐 |
血根碱水合物
Sanguinarine chloride hydrate (订货以英文为准)
编号:S101540
CAS号:5578-73-4
分子式:C20H14CLNO4
分子量:367.78
产品名称 | Sanguinarine chloride hydrate |
中文名称 | 血根碱水合物 |
CAS号 | 5578-73-4 |
分子式(M.F.) | C20H14CLNO4 |
分子量(M.W.) | 367.78 |
Reaxys-RN | 97825 |
Merck Index | 8200 |
个人防护设备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
RTECS | VJ1400000 |
WGK德国 | 1 |
安全声明(欧洲) | S24/25; |
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