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GW843682X,PLK1和PLK3的抑制剂

GW843682X （订货以英文为准）

编号：G127325
CAS号：660868-91-7
分子式：C22H18N3O4F3S
分子量：477.46
货号 品牌 包装 目录价 您的价格 库存 数量 购买
G127325-25mg 阿拉丁 25mg ¥1739.90
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G127325-100mg 阿拉丁 100mg ¥5639.90
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G127325-5mg 阿拉丁 5mg ¥519.90
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G127325-10mg 阿拉丁 10mg ¥789.90
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G127325-50mg 阿拉丁 50mg ¥3129.90
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产品名称 GW843682X
中文名称 GW843682X,PLK1和PLK3的抑制剂
CAS号 660868-91-7
分子式（M.F.） C22H18N3O4F3S
分子量（M.W.） 477.46
储存条件 -20°C储存
溶解性DMSO
存贮条件储存温度-20°C
应用A cell-permeable thiophene-benzimidazole compound and reversible PLK inhibitor
产品介绍GW843682X是PLK1和PLK3抑制剂，IC50分别为2.2 nM和9.1 nM，比对其它30种激酶的抑制性高超过100倍。
生化机理Polo-like Kinase Inhibitor III (GW843682X) is a cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against Plk (polo-like kinases) (Ki against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Polo-like Kinase Inhibitor III preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 μM) over normal human diploid fibroblasts (IC50 = 6.14 μM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.
别名GW 843682X;GW843682;GW-843682X;3-(2-(三氟甲基)苄氧基)-5-(5,6-二甲氧基-1H-苯并(d)咪唑-1-基)-2-噻吩甲酰胺;;GW 843682X;GW843682;GW-843682X; 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide ; 3-(2-(trifluoromethyl)benzyloxy)-5-(5,6-dimethoxy-1h-benzo(d)imidazol-1-yl)thiophene-2-carboxamide; polo-like kinase inhibitor iii
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