| 敏感性 | 对热敏感; 对空气敏感 |
| 溶解性 | Soluble in water (partly), ethanol, DMSO (>10 mg/ml), methanol, and chloroform. |
| 存贮条件 | 充氩保存; 储存温度2-8℃ |
| 应用 | Desloratadine是人H1受体拮抗剂。 |
| 产品介绍 | Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro. |
| 生化机理 | It is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects. |
| 别名 | 脱羧氯雷他定;地氯雷他定;地洛他定;8-氯-6,11-二氢-11-(4-哌啶烯基)-5H-苯并[5,6]环庚基[1,2-b]吡啶;8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine |
脱羧氯雷他定
Desloratadine （订货以英文为准）
编号：D155989
CAS号：100643-71-8
分子式：C19H19CLN2
分子量：310.82
| 产品名称 | Desloratadine |
| 中文名称 | 脱羧氯雷他定 |
| CAS号 | 100643-71-8 |
| 分子式（M.F.） | C19H19CLN2 |
| 分子量（M.W.） | 310.82 |
| 储存条件 | 2-8°C储存;充氩 |
| Reaxys-RN | 2056095 |
| 信号词 | Danger |
| 危害声明 | H315-H319-H335-H350-H360-H410 |
| 警示性声明 | P201-P261-P273-P305 + P351 + P338-P308 + P313-P501 |
| 个人防护设备 | Eyeshields， full-face particle respirator type N100 (US)， Gloves， respirator cartridge type N100 (US)， type P1 (EN143) respirator filter， type P3 (EN 143) respirator cartridges |
| RTECS | WJ5600000 |
| WGK德国 | 3 |
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