| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water. |
| 存贮条件 | 密封避光保存。 |
| 密度 | 1.1280 |
| 应用 | An apoptosis inducer via PKC-dependent signalling pathway. |
| 产品介绍 | Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells. |
| 生化机理 | Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. EC50 concentrations for activation of FXR range from 13-34 μM. In cells, Chenodeoxycholic Acid also binds to bile acid binding proteins (BABP) with a reported stiochiometery of 1:2. Chenodeoxycholic Acid toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess Chenodeoxycholic Acid contributes to liver and intestinal cancers. |
| 别名 | 脱氧鹅胆酸;鹅脱氧胆酸;3α,7α-二羟基胆质酸;3α,7α-二羟基-5-β-胆烷酸;脱氧脲苷;护肝素3α,7α-Dihydroxy-5β-cholanic acid;5β-Cholanic acid-3α,7α-diol Chenodiol;5β-Cholanic Acid-3α,7α-diol |
鹅去氧胆酸
Chenodeoxycholic acid （订货以英文为准）
编号：C104902
CAS号：474-25-9
分子式：C24H40O4
分子量：392.57
| 产品名称 | Chenodeoxycholic acid |
| 中文名称 | 鹅去氧胆酸 |
| CAS号 | 474-25-9 |
| 分子式（M.F.） | C24H40O4 |
| 分子量（M.W.） | 392.57 |
| 储存条件 | 2-8°C储存;避光 |
| 标识符号 | https://www.aladdin-e.com/images/ghs/ghs07.jpg |
| 信号词 | Warning |
| 危害声明 | H315;H319;H335 |
| 警示性声明 | P261;P305+P351+P338 |
| 个人防护设备 | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| WGK德国 | 3 |
| 风险声明 (欧洲) | R36/37/38 |
| 安全声明（欧洲） | S26;S36 |
| 危害码（欧洲） | Xi |
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