3,3'-二乙基氧代二羰花青碘化物

3,3'-Diethyloxadicarbocyanine Iodide (订货以英文为准)

编号:D155285
CAS号:14806-50-9
分子式:C23H23IN2O2
分子量:486.35
货号 品牌 包装 目录价 您的价格 库存 数量 购买
D155285-200MG 阿拉丁 200MG ¥711.00
D155285-50mg 阿拉丁 50mg ¥381.90
D155285-5g 阿拉丁 5g ¥7599.00
D155285-250mg 阿拉丁 250mg ¥957.90
D155285-1g 阿拉丁 1g ¥1802.90
产品名称 3,3'-Diethyloxadicarbocyanine Iodide
中文名称 3,3'-二乙基氧代二羰花青碘化物
CAS号 14806-50-9
MDL编码 D155285
分子式(M.F.) C23H23IN2O2
分子量(M.W.) 486.35
别名;['DODC Iodide', '5-(3-Ethylbenzoxazol-2-ylidene)-1-(3-ethylbenzoxazolium-2-yl)-1,3-pentadiene Iodide', '3-Ethyl-2-[5-(3-ethyl-2-benzoxazolinylidene)-1,3-pentadienyl]benzoxazolium Iodide']
Reaxys-RN2117791

技术规格

Background: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
Applications: WB
Name of antibody: TRIM28
Immunogen: Synthetic peptide of human TRIM28
Full name: tripartite motif containing 28
Synonyms: KAP1; TF1B; RNF96; TIF1B
SwissProt: Q13263
WB Predicted band size: 89 kDa
WB Positive control: Jurkat, T98G, COS7 and Hela cells
WB Recommended dilution: 500-1000
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