别名 | ;['DODC Iodide', '5-(3-Ethylbenzoxazol-2-ylidene)-1-(3-ethylbenzoxazolium-2-yl)-1,3-pentadiene Iodide', '3-Ethyl-2-[5-(3-ethyl-2-benzoxazolinylidene)-1,3-pentadienyl]benzoxazolium Iodide'] |
3,3'-二乙基氧代二羰花青碘化物
3,3'-Diethyloxadicarbocyanine Iodide (订货以英文为准)
编号:D155285
CAS号:14806-50-9
分子式:C23H23IN2O2
分子量:486.35
产品名称 | 3,3'-Diethyloxadicarbocyanine Iodide |
中文名称 | 3,3'-二乙基氧代二羰花青碘化物 |
CAS号 | 14806-50-9 |
MDL编码 | D155285 |
分子式(M.F.) | C23H23IN2O2 |
分子量(M.W.) | 486.35 |
Reaxys-RN | 2117791 |
技术规格
Background: | Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. |
Applications: | WB |
Name of antibody: | TRIM28 |
Immunogen: | Synthetic peptide of human TRIM28 |
Full name: | tripartite motif containing 28 |
Synonyms: | KAP1; TF1B; RNF96; TIF1B |
SwissProt: | Q13263 |
WB Predicted band size: | 89 kDa |
WB Positive control: | Jurkat, T98G, COS7 and Hela cells |
WB Recommended dilution: | 500-1000 |
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