| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.; DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | An indoledione caspase activator |
| 产品介绍 | Apoptosis Activator 2强诱导caspase-3激活， PARP分裂， DNA断裂，导致细胞破坏(Apaf-1依赖性的)，IC50约为4 μM，抑制HMEC， PREC和MCF-10A细胞活性。 |
| 备注 | Apoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. |
| 生化机理 | Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3. |
| 别名 | 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮;凋亡活化剂 2;1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione |
1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮
Apoptosis Activator 2 （订货以英文为准）
编号：A129309
CAS号：79183-19-0
分子式：C15H9CL2NO2
分子量：306.14
| 产品名称 | Apoptosis Activator 2 |
| 中文名称 | 1-(3,4-二氯苄基)-1H-吲哚-2,3-二酮 |
| CAS号 | 79183-19-0 |
| 分子式（M.F.） | C15H9CL2NO2 |
| 分子量（M.W.） | 306.14 |
| 储存条件 | 2-8°C储存 |
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