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Dinaciclib (SCH727965),新型CDK抑制剂

Dinaciclib (SCH727965) （订货以英文为准）

编号：D127362
CAS号：779353-01-4
分子式：C21H28N6O2
分子量：396.49
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D127362-100mg 阿拉丁 100mg ¥3249.90
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D127362-5mg 阿拉丁 5mg ¥339.90
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D127362-25mg 阿拉丁 25mg ¥1019.90
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产品名称 Dinaciclib (SCH727965)
中文名称 Dinaciclib (SCH727965),新型CDK抑制剂
CAS号 779353-01-4
分子式（M.F.） C21H28N6O2
分子量（M.W.） 396.49
储存条件 -20°C储存
熔点107-111° C
溶解性DMSO: ≥ 56 mg/mL
存贮条件储存温度-20°C
应用A novel and potent cyclin-dependent kinase inhibitor for Cdk2, Cdk5, Cdk1, and Cdk9
产品介绍Dinaciclib (SCH727965)是CDK抑制剂，对CDK2，CDK5，CDK1和CDK9的IC50分别为1 nM，1 nM，3 nM和4 nM。
备注Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM, respectively. It also blocks thymidine (dThd) DNA incorporation. Phase 3.
生化机理Dinaciclib(SCH 727965 ) is a pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib(SCH 727965 ) selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis.
别名SCH 727965; (2S)-1-(3-乙基-7-(((1-氧代-3-吡啶基)甲基)氨基)吡唑并(1,5-a)嘧啶-5-基)-2-哌啶乙醇;;SCH727965; SCH-727965;(2s)-1-(3-ethyl-7-(((1-oxido-3-pyridinyl)methyl)amino)pyrazolo(1,5-a)pyrimidin-5-yl)-2-piperidineethanol

技术规格

Background: The function of this protein remains unknown.
Applications: ELISA, WB, IHC
Name of antibody: RPUSD2
Immunogen: Fusion protein of human RPUSD2
Full name: RNA pseudouridine synthase domain containing 2
Synonyms: PUS9; C18B11; C15orf19
SwissProt: Q8IZ73
ELISA Recommended dilution: 5000-10000
IHC positive control: Human gastric cancer and Human tonsil
IHC Recommend dilution: 150-300
WB Predicted band size: 61 kDa
WB Positive control: Hela, 231 and 293T cell lysates
WB Recommended dilution: 1000-5000
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